
How long MACI lasts after knee surgery
MACI grafts improve substantially over two years then remain stable through a decade; 92% report lasting pain relief but only 76% return to sport.
London Cartilage Clinic
Explore expert articles on cartilage care, regenerative treatments, and practical recovery advice from our specialist team.

MACI grafts improve substantially over two years then remain stable through a decade; 92% report lasting pain relief but only 76% return to sport.

Advanced knee osteoarthritis is not a single-tissue disorder: Grade III/IV disease simultaneously damages the articular cartilage (removing structural support) and the synovial membrane (perpetuating inflammation), leaving single-injection treatments unable to address both sites.

High tibial osteotomy delays or prevents total knee replacement in roughly 60–80% of appropriately selected patients by ten years. The procedure corrects varus deformity—the bow-legged misalignment concentrating destructive load on a single knee compartment—by shifting that load toward intact cartilage.

Cartilage has no blood supply; movement pumps synovial fluid through its matrix to feed chondrocytes, so immobilisation after injury actively harms the tissue independent of the original damage.

The ChondroFiller pathway for knee cartilage damage is determined by geometry: diffuse wear uses ultrasound-guided injection; focal, contained defects use either injection or the surgical Liquid Cartilage procedure.

Bone-plug transfer suits focal talar defects where subchondral bone is damaged, in younger active patients; it restores native hyaline cartilage and bone simultaneously, producing repairs that endure a decade where microfracture's fibrocartilage alternative breaks down in two to three years.