Cartilage
Knees
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Unlocking Regenerative Potential: How ChondroFiller Bridges the Gap in Cartilage Self-Repair
22/09/25
Innovative Long‑Term Relief with Arthrosamid® at London Cartilage Clinic
Breaking New Ground in Knee Arthritis Care
At London Cartilage Clinic, we pioneered a long-lasting, non-surgical solution for knee osteoarthritis. Backed by our peer-reviewed study, “Polyacrylamide hydrogel injections in knee osteoarthritis: A PROMs-based 24-month cohort study”, provides real-world, two-year evidence of long-term outcomes in everyday clinical settings.
Bringing Evidence to Non‑Surgical Knee OA Care
Knee osteoarthritis is a leading cause of pain, reduced mobility, and loss of independence. For years, patients have had limited options: painkillers, steroid injections, and eventually, knee replacement surgery.
London Cartilage Clinic has completed one of the largest two-year follow-up studies on Arthrosamid®, an injectable hydrogel intended to cushion the knee joint. Our published research “Polyacrylamide hydrogel injections in knee osteoarthritis: A PROMs-based 24-month cohort study”, followed patients treated in routine orthopaedic clinics to understand real-world outcomes over time.
- Duration
- Two years
- Participants
- 269 people
- Knees Assessed
- 314 knees
- Setting
- Real‑world clinics
Source: Polyacrylamide hydrogel injections in knee osteoarthritis: A PROMs-based 24 month cohort study
What Is Arthrosamid®?
Arthrosamid® is an innovative injectable hydrogel made from cross‑linked polyacrylamide and water. Once placed inside the knee joint, it becomes part of the joint lining and acts as a soft, shock‑absorbing cushion.
Understanding knee osteoarthritis
Knee osteoarthritis occurs when the cartilage that cushions the joint wears down.
- Persistent pain during movement
- Stiffness after rest
- Swelling or grinding sensations
- Difficulty with stairs, walking, or standing for long periods
Conventional treatments often provide only temporary relief.
Two‑Year Clinical Study: Key Findings
We followed 269 people (314 knees) over two years after a single Arthrosamid injection in real‑world orthopaedic clinics. Reported outcomes included:
Results highlights
Reduced pain
Reported following a single Arthrosamid injection.
Improved walking ability
Observed in real‑world orthopaedic clinics.
Greater joint flexibility
Part of the functional improvements reported.
Best response in earlier stages
Patients with mild‑to‑moderate knee wear saw the greatest benefits.
Sustained functional gains
Many patients did not require repeat injections over two years.
The scale and duration make this one of the most comprehensive real‑world datasets available. These observations suggest that a single injection may provide long‑term benefits for selected patients.
