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London Cartilage Clinic IconLondon Cartilage Clinic66 Harley Street
Surgical procedure for cartilage transplantation

OCA Replacement

From £28,000
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Guide price only. Final cost is confirmed after assessment.

Osteochondral allograft (OCA) transplantation replaces large areas of damaged cartilage and bone with fresh donor tissue, matched to the size and location of your defect. It is a single-stage procedure suited to patients with significant cartilage loss who are too young or too active for joint replacement. At London Cartilage Clinic, we have extensive experience with allograft surgery and work with accredited tissue banks to source the highest quality donor tissue available.

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Prof Paul LeeReviewed byProf Paul LeeLast reviewed 1 May 2026
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How OCA transplantation restores the joint surface

OCA involves transplanting a precisely shaped plug of cartilage and bone from a donor into the prepared defect site in your knee. The graft is press-fitted to achieve a congruent, stable surface that matches the contour of the surrounding cartilage.

  • Fresh allograft tissue contains living chondrocytes that can survive and function in the joint.
  • The bone component integrates with the host bone to provide structural support.
  • Capable of treating large defects that exceed the capacity of autograft techniques.

OCA is particularly valuable for younger patients facing a decision between living with a significant cartilage defect and undergoing joint replacement. It fills the gap where other cartilage procedures cannot.

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Recovery and expected outcomes

Recovery after OCA transplantation is deliberate. The graft needs time to incorporate into the bone and for the cartilage surface to mature under protected conditions.

  • Protected weight-bearing for six to eight weeks using crutches.
  • Range of motion exercises begin immediately to maintain joint flexibility.
  • Gradual return to sport from six to twelve months based on graft maturation.

Published outcomes show that OCA provides durable pain relief and functional improvement in the majority of patients, with many grafts lasting ten years or more.

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You may have more options than you think

Most patients have more treatment options than they have been told

At London Cartilage Clinic we follow a structured clinical framework across four areas of treatment. Before recommending a single procedure, we assess which combination of approaches gives you the best outcome.

Preserve

Protect what you have. Slow degeneration and manage symptoms.

Repair

Fix specific damage. Torn tissue, unstable joints, structural problems.

Regenerate

Rebuild lost tissue. Biological treatments that stimulate new growth.

Replace

When other options are exhausted. Joint replacement as a last resort.

Explore the full range of treatments available for your joint. Each hub page shows every option we offer, organised by clinical approach.

Explore Knee Options
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Frequently Asked Questions

What is an osteochondral allograft?

An osteochondral allograft is a section of cartilage and underlying bone harvested from a tissue donor. It is size-matched to the defect in your joint and transplanted in a single surgical procedure. The graft provides living cartilage cells on a structural bone scaffold, allowing it to integrate with your own tissue over time.

How is the donor tissue sourced and is it safe?

Donor tissue is sourced through accredited tissue banks that screen extensively for infectious disease and tissue quality. Fresh allografts are stored and transported under strict protocols to preserve cell viability. The safety profile is well established with decades of clinical use.

Who is a candidate for OCA transplantation?

OCA is typically recommended for patients with large focal cartilage defects, often greater than two square centimetres, who are too young or active for joint replacement. It is also an option for patients who have had a previous cartilage procedure that has not succeeded.

How does OCA differ from OATS?

OATS uses your own cartilage plugs from a non-weight-bearing area, which limits the amount of tissue available. OCA uses donor tissue, which allows much larger defects to be treated in a single stage without a secondary donor site on your own knee.

What is the recovery time after OCA transplantation?

Weight-bearing is restricted for six to eight weeks to protect the graft while it integrates. Physiotherapy begins early to maintain range of motion. Return to low-impact activity is typically possible from four to six months, with higher-impact sport from nine to twelve months.

Still have more specific concerns?

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