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PRF (Platelet Rich Fibrin) represents a new approach in the field of orthopaedic medicine, particularly in cartilage repair. At the London Cartilage Clinic, we specialise in PRF therapy to address knee cartilage injuries. This technique involves using a patient's own blood to create a concentrated source of platelets and growth factors, aiding in the natural healing process.
Reviewed byProf Paul Lee MBBch, FRCS (Tr & Orth), PhDLast reviewed 1 May 2026
PRF (platelet-rich fibrin) is an autologous blood-derived matrix that delivers platelets and growth factors in a sustained-release form.
Compared with standard PRP preparations, PRF provides a fibrin scaffold that may support a longer biological effect at the treatment site.
PRF is used at our clinic to improve the biological environment in tissues with limited self-healing capacity, especially in the knee.
We use PRF where it is clinically appropriate, with transparent expectations around recovery, symptom response, and potential need for combined therapies.
You may have more options than you think
At London Cartilage Clinic we follow a structured clinical framework across four areas of treatment. Before recommending a single procedure, we assess which combination of approaches gives you the best outcome.
Protect what you have. Slow degeneration and manage symptoms.
Fix specific damage. Torn tissue, unstable joints, structural problems.
Rebuild lost tissue. Biological treatments that stimulate new growth.
When other options are exhausted. Joint replacement as a last resort.
This treatment can be applied across multiple joints. Select yours to see the full range of options we offer, organised by clinical approach.
Explore All Treatment Options
PRF is a second-generation platelet concentrate, richer and more effective than its predecessor, PRP. It is created from the patient’s own blood and is used to accelerate the healing of injured tissues, including cartilage.
In PRF therapy, a concentration of platelets and growth factors is applied directly to the injured cartilage site. This method promotes natural healing and regeneration of the cartilage tissue, particularly in the knee.
PRF therapy is suitable for individuals suffering from cartilage injuries, particularly in the knee. It is especially beneficial for patients looking for a natural and minimally invasive treatment option.
PRF offers a natural, autologous approach to healing, reducing the risk of rejection and complications. Its slow release of growth factors provides a sustained healing environment, enhancing the overall efficacy of cartilage repair.
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Clinical updates, cartilage treatment guidance, and recovery-focused articles from our specialist team.
ChondroFiller injection achieves symptom relief in 70–85% of patients, with a reoperation rate of 3–8% — substantially lower than microfracture's 41% or ACI's 37%.
Partial ACL tears develop silently through repetitive loading and remain unnoticed until roughly half the ligament's fibres fail. MRI misidentifies tear patterns in more than six out of ten cases, making these injuries easy to overlook.
Talar cartilage defects resist self-repair owing to poor blood supply and continuous mechanical stress. ChondroFiller is an injectable collagen that sets into a hydrogel and recruits the body's own repair cells, delivered by ultrasound guidance without surgery.
