ChondroFiller pathway
CFI++ChondroFiller Injection + MSC + Arthrosamid
Our most complete regenerative approach for very worn joints, even bone on bone. A hopeful alternative to joint replacement. From £10,500.
Reviewed byProf Paul Lee MBBch, FRCS (Tr & Orth), PhDLast reviewed 1 May 2026Non-surgical
Injections, no incision
Even bone on bone
For very worn joints
Your own cells
MSC included as core
From £10,500
Confirmed at consultation
How CFI++ works
Three layers, one visit
- 1
CFI (ChondroFiller Injection) rebuilds and cushions the worn surface, laying a fresh collagen scaffold over the damaged joint.
- 2
MSC (Medicinal Signalling Cells), your own repair cells, supercharge the regeneration from inside the scaffold, adding the biological signal that drives new tissue formation.
- 3
Arthrosamid protects the joint lining, calming inflammation and slowing further degeneration to give the rebuilding process the best possible environment.
ChondroFiller and your own MSC rebuild the cartilage together, while Arthrosamid lines and protects the joint.
A hopeful alternative
Every advantage, before replacement
When a joint is very worn, even bone on bone, the conventional answer is replacement. CFI++ is for patients who want to explore every joint-preserving option first. It combines the three things that help a worn joint most: a fresh surface, a biological boost, and a protected environment to rebuild in.
We are honest about what this can and cannot do. The outcomes for very worn joints are supported by early evidence, and for some joints replacement remains the right answer. Professor Lee will tell you plainly which path fits your joint after reviewing your scans.
Candidate Profile
Who is CFI++ for?
CFI++ is for patients with very worn or bone-on-bone joints who want to explore every joint-preserving option before committing to replacement. The right fit is confirmed at consultation with an imaging review.
Good candidates may include
- Very worn or bone-on-bone joints, where cartilage loss is advanced
- Patients wanting to delay or avoid joint replacement
- Joints that are both severely worn and inflamed or reactive
- Patients who want to give their joint the maximum regenerative support available
- Any joint: knee, hip, shoulder, ankle, elbow, foot or hand
Where caution is needed
- A focal early defect: CFI or CFI+ may be a simpler, more appropriate fit
- Where joint replacement is genuinely the right answer: Professor Lee will say so honestly
- Untreated joint instability or major malalignment
- Active infection (joint or systemic)
- Mechanical locking or catching: may need the keyhole Liquid Cartilage™ pathway instead
Find Your Pathway
ChondroFiller® Suitability Assessment
Eight short questions, around two minutes. Get a personal pathway from a ChondroFiller Injection to a keyhole procedure or a combination plan, with a clear next step.
- No age limit — bone on bone doesn't rule you out
- A clear, personal result you can bring to your consultation
Around 2 minutes · Guidance only — not a diagnosis.
A core part of this approach
Your own living cells, working inside the scaffold
This approach pairs the ChondroFiller scaffold with MSC (Medicinal Signalling Cells), your body's own repair cells, in the same visit. The scaffold gives new tissue a structure to form into; the cells add the biological signal that supports the rebuilding. In early studies the combination has shown even greater improvement than the scaffold alone.
Harvest, on the day
Your own Medicinal Signalling Cells (MSC) are gently harvested during your appointment, from bone marrow, fat or platelet-rich fibrin. The source is chosen with you at consultation.
Load into the scaffold
The cells are placed inside the ChondroFiller collagen scaffold. The scaffold holds them exactly where they are needed, so they stay put rather than dispersing.
Stay and rebuild
Held in place, the cells add a biological signal that supports the cells doing the rebuilding, working alongside the scaffold to drive regeneration.
The cell source and handling are agreed at your consultation with Professor Lee.
Why London Cartilage Clinic
Pioneers of ChondroFiller as an injection
A UK first
London Cartilage Clinic was the first UK clinic to offer ChondroFiller® as an injection.
Led by Professor Lee
Your treatment is led by Professor Paul Y.F. Lee, consultant orthopaedic surgeon.
Harley Street
Consultations take place at our clinic on Harley Street in central London.
Preservation first
We aim to preserve your own joint, and we say so honestly when replacement is the right answer.
Cost
From £10,500
CFI++ bundles two injection packs plus the MSC component. The two-pack injection tier covers one ChondroFiller injection and one Arthrosamid injection; the MSC component is included in the from price. The exact number of ChondroFiller packs your joint needs is confirmed at consultation following an imaging review.
If you do not have a recent MRI scan, one can be arranged from £450. The consultation and scan review are the right first step to confirm whether CFI++ is the appropriate approach for your joint.
CFI++
Frequently asked questions
What is CFI++?
CFI++ is our most complete regenerative approach for very worn joints. A CFI (ChondroFiller Injection) rebuilds and cushions the worn surface, your own MSC (Medicinal Signalling Cells) supercharge regeneration from inside the scaffold, and Arthrosamid protects the joint lining. All three elements are delivered without surgery, in a single visit.
Is CFI++ really an alternative to joint replacement?
CFI++ is a hopeful, joint-preserving option for very worn joints, supported by early evidence. For patients who want to delay or avoid replacement it offers meaningful biological support. That said, for some joints replacement is still the right answer, and Professor Lee will say so honestly at consultation. If you want to explore where joint preservation may help and where it may not, read our guide on ChondroFiller vs knee replacement.
How much does CFI++ cost?
CFI++ is from £10,500. It is a "from" price: it bundles the two-pack injection tier plus the MSC component. The exact number of ChondroFiller packs your joint needs is confirmed at consultation following an imaging review.
Is CFI++ surgery?
No. CFI++ is delivered as injections in clinic, under image guidance. There is no general anaesthetic and no incision. If your joint needs a keyhole approach instead, Professor Lee will discuss the Liquid Cartilage™ surgical pathway at your consultation.
Continue Exploring
Useful context for your decision
CFI+ Combination
ChondroFiller + Arthrosamid without the MSC step. From £5,500.
Read about CFI+Liquid Cartilage™ Surgery (LCS)
The keyhole route, pairing ChondroFiller with MSC under arthroscopic vision. Flat £9,800.
Read about LCSChondroFiller vs Knee Replacement
Where joint preservation may help and where replacement is the right answer.
See the comparisonChondroFiller® is a registered trademark of Meidrix Biomedicals GmbH. Liquid Cartilage™ is a London Cartilage Clinic technique combining ChondroFiller® with medicinal signalling cells. London Cartilage Clinic is not affiliated with or endorsed by Meidrix Biomedicals.