Evidence from
Real Clinical Practice
Our use of Arthrosamid® is informed by an independent, clinician-led clinical study, carried out as part of routine specialist knee care.
This study was not sponsored, funded, or commissioned by the manufacturer. It reflects real patient outcomes, rather than promotional or product-led data.
Arthrosamid® (a registered trademark of Contura A/S.).
Reviewed byProf Paul Lee MBBch, FRCS (Tr & Orth), PhDLast reviewed 1 May 2026Study Overview
This comprehensive evaluation provides a window into the long-term efficacy of Arthrosamid® treatments within a standard clinical setting.
Patients were reviewed over time to understand both the durability of symptom improvement and longer-term progression, including whether knee replacement was later required.
269 Patients
Total participants enrolled
314 Knees
Treated with specialist care
Bilateral Treatment: Some patients received injections in both knees where clinically appropriate.
What We Followed
Patients were assessed at baseline and during follow-up using established, patient-reported outcome measures:
- Pain (Visual Analogue Score – VAS)
- Function (Oxford Knee Score – OKS)
- Knee performance (Lysholm Score)
We also recorded:
- Age and common medical conditions (such as diabetes)
- Arthritis severity
- Whether one or both knees were injected
- Complications and tolerance
- Progression to total knee replacement over time
Meaningful improvement was defined using clinically important change thresholds, focusing on outcomes that patients actually feel in daily life.
What We Learned
"From this independent clinical study, we observed that Arthrosamid®can provide sustained improvement in pain and function for up to two years in appropriately selected patients."
Patients were more likely to benefit when they:
- Were older adults
- Had mild to moderate knee osteoarthritis
- Did not have diabetes
- Received bilateral knee injections
- Had realistic expectations focused on improvement rather than cure
Patients with more advanced arthritis were more likely to progress to knee replacement, even if short-term symptom relief occurred.
How This Study Shapes
Patient Care
This study directly informs how we use Arthrosamid® in clinic:
Not a Routine Injection
It is not offered as a standard option for every patient, ensuring targeted treatment.
Structured Assessment
Suitability is assessed carefully using our structured Arthrosamid® suitability questionnaire.
Open Discussion
Benefits, limitations, and alternatives are discussed openly with every patient.
Joint-Preservation Strategy
Used as part of a long-term strategy, not a replacement for necessary surgery.
Why This Matters for You
Because our clinical study is independent and clinician-led,
we are able to give:
Balanced
advice
Honest
expectations
Clear guidance on whether
Arthrosamid® is likely to help you
Good outcomes come from good decisions — not just injections.
Am I Suitable?
Take the Arthrosamid® Suitability Assessment
Eight quick questions to support a shared decision-making conversation about Arthrosamid®. Your answers stay with you across visits, so you can pick up where you left off.
Will Arthrosamid work for me?
Arthrosamid® suitability questionnaire
Completed 0/8
Question 1 of 8
How old are you?
Older age associated with higher odds of benefit in your cohort.
Please select an option before moving to the next question.
From Evidence to Decision
What this means if you are considering Arthrosamid®
Evidence helps guide suitability. The outcome data on this page is useful because it tells us who is likely to benefit and who is not. The decision is patient-specific and made at consultation.
Not every patient should have Arthrosamid®. A clinic willing to decline unsuitable cases is selecting for outcomes. We do decline cases where Arthrosamid® is unlikely to help.
Patient selection matters. The same outcome data shifts dramatically by stage of arthritis, comorbidities, body weight and activity level. The published series is an average; your case is specific.
Results vary. Some patients have two years of relief, some have longer, some shorter. We will tell you what to expect for your specific case, in writing, at consultation.
Advanced arthritis may still progress to knee replacement. Arthrosamid® is not a cure and does not regenerate cartilage. Where knee replacement is the clinically appropriate answer, we will say so.
Clinical Evidence
Frequently asked questions
Does Arthrosamid® really work for knee osteoarthritis?
Yes — in suitable patients. Published clinical evidence and our own real-world outcome data from over 600 treated patients show on average two to three years of meaningful symptom relief from a single Arthrosamid® injection. Individual outcomes vary by stage of arthritis, body weight, activity level and adherence to the recovery protocol. Not every knee osteoarthritis patient is a candidate.
How long do Arthrosamid® results last?
Most patients report meaningful improvement at four to six weeks, with continued benefit established by twelve weeks. Published outcome data for the knee shows on average two to three years of symptom relief from a single injection. Some patients experience longer benefit, some shorter; we will tell you, in writing at consultation, what to expect for your specific case.
Who responds best to Arthrosamid®?
Patients with diagnosed knee osteoarthritis, mild-to-moderate cartilage wear, symptoms despite conservative treatment, realistic expectations and a desire to delay more invasive treatment tend to respond best. Patients with end-stage bone-on-bone arthritis or active infection are less suitable. See the Arthrosamid® suitability self-assessment for a structured indication of fit.
What happens if Arthrosamid® does not work for me?
A minority of patients do not get the expected level of relief. If symptoms have not improved by twelve weeks we re-review imaging and clinical findings, discuss whether a further box would be appropriate, and consider alternative pathways. Where end-stage arthritis is the underlying issue, knee replacement may be the better answer; we will say so honestly.
Is the Arthrosamid® evidence peer-reviewed?
Yes. Arthrosamid® has a peer-reviewed evidence base across multiple international centres, and Professor Paul Lee’s published fifteen-step injection protocol is part of that literature. The real-world outcome data on this page comes from over 600 patients treated at London Cartilage Clinic and is the largest UK series available.
Will Arthrosamid® prevent me from needing a knee replacement?
Arthrosamid® is not a substitute for knee replacement where replacement is clinically appropriate. In selected patients with mild-to-moderate osteoarthritis, Arthrosamid® may help delay the need for surgery. In advanced bone-on-bone arthritis the disease may progress regardless. We will tell you, honestly, whether knee replacement is the better answer for your stage.
Book an Arthrosamid® Assessment – London
Long-lasting relief starts with the right decision — not just an injection.
Learn More about Arthrosamid
Deep dive into our clinical resources and patient guides.
Cost in the UK
Arthrosamid® cost in the UK from £3,000, what is included and why prices vary.
NHS & Insurance
Is Arthrosamid® available on the NHS or private insurance?
Suitability
Who is suitable for Arthrosamid® — and who may need caution.
Clinical Evidence
Real-world outcome data and what the evidence means for patients.
Side Effects & Safety
Arthrosamid® side effects, risks, complications and clinical context.
Infection Risk
Arthrosamid® infection risk, prevention protocol and IV antibiotic policy.
In London
Private Arthrosamid® treatment at our Harley Street clinic.
Self-Assessment
Eight-question Arthrosamid® suitability self-assessment tool.
Full FAQ
Arthrosamid® patient FAQ across cost, suitability, safety and comparisons.
vs Hyaluronic Acid
Arthrosamid® compared to hyaluronic acid injections.
vs PRP
Arthrosamid® compared to PRP for knee osteoarthritis.
vs Steroid Injection
Arthrosamid® compared to corticosteroid injection.
vs Knee Replacement
Where Arthrosamid® may help delay surgery — and where it cannot.
Arthrosamid® Injection
Comprehensive Overview
Arthrosamid® is a registered trademark of Contura A/S. London Cartilage Clinic is not affiliated with or endorsed by Contura A/S.