Living with knee osteoarthritis can feel like an ongoing challenge. Pain, stiffness, and reduced movement can turn even the simplest activities into hurdles, making day-to-day life less enjoyable. Roughly one in five people over 45 in England face this condition. While many available treatments offer only brief relief, there’s growing interest in new, minimally invasive options that promise longer-term benefits. Arthrosamid ® is one such innovation. This injectable hydrogel is delivered directly into the knee joint , where it cushions and lubricates, offering extended comfort and mobility without surgery. For many, it provides a real opportunity for lasting improvement.

Understanding Knee Osteoarthritis

Knee osteoarthritis is a common condition that develops as the protective cartilage in the knee gradually wears away. When cartilage breaks down, bones start to rub together, leading to pain, swelling, and inflammation of the joint lining (the synovium). Stiffness and restricted movement are everyday issues for those with knee OA —often measured through tools like the Visual Analogue Scale (VAS) for pain and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) for function. Recent studies have shown that certain treatments, such as knee joint traction, can help relieve symptoms and improve movement. Beyond the physical discomfort, knee osteoarthritis can also affect mental health, making it important to find effective, long-term solutions for better overall wellbeing.

How Arthrosamid Works: Mechanism and Benefits

Arthrosamid ® is a hydrogel made up of 97.5% water blended with a small amount of cross-linked polyacrylamide. This creates a soft, stable gel that forms a cushion inside the knee joint . The treatment is given as a single injection , usually under local anaesthetic and guided by ultrasound for accuracy. Once inside the joint, Arthrosamid® thickens the natural joint fluid , improving lubrication and easing the movement between bones, which leads to less pain and stiffness. The hydrogel also integrates with the lining of the joint, providing a supportive buffer and additional protection. Clinical studies have shown that patients experience significant reductions in pain and improvements in joint function, with benefits lasting for up to two years. Importantly, Arthrosamid® has shown a strong safety profile, with no serious long-term side effects reported. This makes it a promising choice for people seeking sustained relief from knee osteoarthritis without surgery.

Everyday Comfort and Mobility Improvements

Patients who receive Arthrosamid® often notice a real difference within months. In studies, scores measuring pain and movement , such as the WOMAC, show clear improvement at three, six, and twelve months after injection, with many experiencing continued benefits for up to two years. The treatment seems to be particularly useful for older adults and those with milder osteoarthritis . For example, some patients are able to walk outdoors more comfortably, reduce or even stop taking pain medication, or return to gentle exercise. These changes don’t just make daily life easier—they can also lift mood and encourage social connection. By relieving pain and helping restore joint movement, Arthrosamid ® supports a more active, fulfilling lifestyle.

Professional Care at London Cartilage Clinic

At the London Cartilage Clinic , Professor Paul Lee leads a team of experts dedicated to treating knee osteoarthritis with care and precision. Patients receive individualised attention, starting with careful assessment to see if Arthrosamid ® is the right solution. The team uses ultrasound to guide injections for greater accuracy and safety, and provides thorough follow-up to monitor recovery and answer any questions. While the clinic does not claim to have invented Arthrosamid ® or guarantee specific results, their expertise ensures every patient receives the best care and support on their journey to better knee health .

Conclusion and Disclaimer

Arthrosamid ® represents an exciting minimally invasive option for those with knee osteoarthritis , offering long-term relief from pain and improved mobility with just a single injection. With the support of knowledgeable clinicians and a focus on personalised care, this treatment can help you regain comfort and confidence in your everyday activities. For individual advice about your health or treatment options, always consult a qualified medical professional.

References

• Bliddal H et al., 2021–2024, multiple studies on PAAG hydrogel efficacy and safety
• Gupta M et al., 2025, RCT on knee joint traction in osteoarthritis
• Dries et al., 2022, study on knee braces and pain management
• Gao, H. C. K., Akhtar, M., Creedon, C., Nar, Ö. O., Verma, T., & Lee, P. Y. F. (2025). Polyacrylamide hydrogel injections in knee osteoarthritis: A PROMs-based 24 month cohort study. Journal of Clinical Orthopaedics and Trauma. https://doi.org/10.1016/j.jcot.2025.103136
• Cole, A., Maulana, R. K., Whitehead, J. P., & Lee, P. Y. F. (2022). A systematic review of the novel compound Arthrosamid polyacrylamide (PAAG) hydrogel for treatment of knee osteoarthritis. Medical Research Archives, 10(8). https://doi.org/10.18103/mra.v10i8.2950