PRF, Platelet Rich Fibrin

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PRF (Platelet Rich Fibrin) represents a new approach in the field of orthopaedic medicine, particularly in cartilage repair. At the London Cartilage Clinic, we specialise in PRF therapy to address knee cartilage injuries. This technique involves using a patient's own blood to create a concentrated source of platelets and growth factors, aiding in the natural healing process.

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Understanding PRF Therapy

PRF therapy is an advanced treatment option for cartilage repair. It is derived from the patient’s own blood, ensuring a high concentration of growth factors essential for tissue regeneration. Unlike its predecessor, PRP (Platelet Rich Plasma), PRF does not require external activation and offers a sustained release of growth factors, promoting effective and long-lasting cartilage repair.

Comparing PRF, PRP, and BMAC

Understanding the differences between Platelet Rich Fibrin (PRF), Platelet Rich Plasma (PRP), and Bone Marrow Aspirate Concentrate (BMAC) is crucial for patients considering regenerative treatments at the London Cartilage Clinic.

PRF vs PRP: While both PRF and PRP are derived from the patient’s blood, PRF is a newer generation therapy that doesn’t require external activation and offers a more sustained release of growth factors. PRP, on the other hand, is a first-generation platelet concentrate some time require activation before use.

PRF vs BMAC: BMAC involves concentrating cells from the patient’s bone marrow, including stem cells, which have regenerative properties. While PRF is primarily platelet-based, BMAC provides a broader range of regenerative cells but may involve a more invasive collection procedure.

The Science Behind PRF

Studies have shown that PRF significantly enhances the healing of cartilage defects. In an animal model, PRF treatment resulted in considerable macroscopic and histological improvements in articular cartilage repair, suggesting its potential benefits in human therapy as well​​​​.

PRF in Knee Cartilage Repair

At London Cartilage Clinic, we use PRF therapy primarily for knee cartilage injuries. Given the avascular nature of hyaline articular cartilage and its limited capacity for self-repair, PRF provides a novel and efficient solution to stimulate regeneration and prevent the progression of osteoarthritis​​.

PRF Augmentation in Meniscus Repair

A promising application of PRF therapy at London Cartilage Clinic involves augmenting the surgical repair of the meniscus. Meniscus tears are common knee injuries, especially among athletes, and can be challenging to heal due to limited blood supply in certain areas. PRF, with its rich concentration of growth factors, can be applied during meniscal surgery to enhance the healing process. This approach aims to improve the biological healing environment, thereby increasing the likelihood of a successful meniscus repair and reducing the risk of future complications or re-tears.


Frequently Asked Questions

PRF is a second-generation platelet concentrate, richer and more effective than its predecessor, PRP. It is created from the patient’s own blood and is used to accelerate the healing of injured tissues, including cartilage​​.

In PRF therapy, a concentration of platelets and growth factors is applied directly to the injured cartilage site. This method promotes natural healing and regeneration of the cartilage tissue, particularly in the knee​​.

PRF therapy is suitable for individuals suffering from cartilage injuries, particularly in the knee. It is especially beneficial for patients looking for a natural and minimally invasive treatment option.

PRF offers a natural, autologous approach to healing, reducing the risk of rejection and complications. Its slow release of growth factors provides a sustained healing environment, enhancing the overall efficacy of cartilage repair.

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